Sauna and Cancer Treatment / Chemotherapy

by admin on June 2, 2011

Ran across this abstract on pubmed:

OBJECTIVE: To determine the short-term efficacy and security of whole body hyperthermia (WBH) combined with chemotherapy for advanced cancer.

METHODS: Different chemotherapy regimens were applied in 138 patients with advanced cancer. Among them, 68 patients (Group A) didn’t receive any other therapies. The other 70 patients (Group B) received WBH together with chemotherapy. WBH was maintained at 40 degrees C approximately 42 degrees C for 50 approximately 60 min (once or twice every week and 4 times a cycle).

RESULTS: In Group A, the rate of complete remission (CR) was 2.9%, partial remission (PR) was 36.8%, stable disease was 35.3%, progressive disease was 25.0%, the overall response rate (CR + PR) was 39.7%; while in Group B, the corresponding figures were 5.7%, 52.9%, 25.7%, 25.0%, and 58.6%, respectively. There was significant difference between the two groups (P < 0.05). The rates of III + IV gastrointestinal tract andmyelosuppression toxicities were 26.5% and 16.2% in Group A, while 27.1% and 18.6% in Group B. No significant difference was found. CONCLUSION: WBH combined with chemotherapy is efficient and safe for advanced cancer, and is worth generalizing extensively. (via.)

{ 0 comments }

Heat and Exercise Effects on Norepinephrine and Catecholamine Storage

by admin on May 26, 2011

Mentioned in a previous post, exposure to heat stress has been demonstrated to cause a release of norepinephrine. This is interesting, mostly, because norepinephrine is the target of a line of drugs known as norepinephrine reuptake inhibitors. These drugs prevent the reuptake of norepinephrine, and thereby treat conditions such as ADHD, and depression. Likewise, some studies have hinted at the fact that sauna use may help with depression.

Here’s a study showing that heat acclimation actually increases the amount of norepinephrine stored within the hypothalamus, at least in rats:

The hypothesis that anterior hypothalamic (AH) sensitivity to norepinephrine (NE) is altered by chronic exercise in the heat was tested in male Sprague-Dawley rats. Treadmill exercise 6 days/wk for 3 wk at 21 m/min was performed at 23 degrees C (control; C) or at 35 degrees C (heat acclimated; HA), progressing from 20 to 50 min/day in 2 wk. Time for core temperature (Tco) to rise from 39.5 to 40.5 degrees C during a heat-tolerance test after conditioning increased (P less than 0.05) in the HA group. To test for a change in AH sensitivity, the change in Tco to 2-, 5-, 10-, 20-, and 40-micrograms doses of NE injected bilaterally into the AH was determined after conditioning. Dose-response regression lines showed that exercise in the heat increased the slope and shifted the Tco-NE dose relation to the left. In a separate series of experiments on 6 sedentary(s), 10 C, and 10 HA animals, the amounts of NE, dopamine, and 3,4-dihydroxyphenylglycol (DOPEG) were determined by high-pressure liquid chromatography in the AH, median preoptic area (PO), cortex, and cerebellum after 9 wk of conditioning. Results showed that in the PO there was a significant increase in NE and DOPEG in the HA vs. C group and a trend of increasing NE from the S to C to HA groups. The data indicate that exercise in the heat increases NE-induced peripheral heat-dissipating capacity and increases catecholamine storage in the PO. (via.)

{ 0 comments }

Use of the Sauna Protecting Against… Noise-Induced Hearing Loss?

May 18, 2011

This is too weird. Check it out… Heat acclimation preventing rats from losing their hearing when exposed to loud noises: Exposure to intense noise stress can cause a permanent noise-induced hearing loss which is thought to be due to elevation of reactive oxygen species in excess of the inherent antioxidant mechanisms of the cell. However, […]

Read the full article →

Sauna Use Reduces Lactate Build Up in Muscles

May 11, 2011

Or, more specifically, heat acclimation reduces the build up of lactate in muscles. Assuming regular use of the sauna, then one might presume that this would result in some level of heat acclimation. Additionally, heat acclimation lowers the aerobic metabolic rate during exercise as well. Perhaps this also plays a role in the enhanced running […]

Read the full article →

Sauna Use and the Prevention of Muscle Atrophy

May 4, 2011

Saunas induce a unique type of stress in individuals known as heat stress. When the body activates the stress system to respond to heat stress some of the same systems that are used during physical exercise, for example, are also activated. Mentioned in a previous post was the fact that hyperthermia has been demonstrated to […]

Read the full article →

Sauna Use Preventing Oxidative Damage in Muscle Tissue

April 27, 2011

Skeletal muscle reloading following disuse is characterized by profound oxidative damage. This study tested the hypothesis that intermittent hyperthermia during reloading attenuates oxidative damage and augments skeletal muscle regrowth following immobilization. […] Heating resulted in ∼25% elevation in heat shock protein expression (P < 0.05) and an ∼30% greater soleus regrowth (P < 0.05) in [...]

Read the full article →

HSP72 and Heart Attack Protection

April 20, 2011

According to a recent study by University of Florida researchers, less than a week’s worth of walking, jogging or cycling can help the heart produce enough HSP72 to protect it against the damage done during a heart attack. “We’ve done studies that indicate that as little as three days of exercise can provide protection,” said […]

Read the full article →

Heat Shock Protein and Oxidative Stress in the Striatum

April 13, 2011

One of the effects of sauna use, or actually almost any heating of tissues, is the release of heat shock protein or “HSP” for short. Heat shock protein is a chaperonin and prevents the unfolding of proteins and helps protect the tissues from damage induced by well, heat, and also other stresses. This study found […]

Read the full article →

Sauna Causes Release of Norepinephrine and Prolactin

April 6, 2011

… and not just a little bit, but quite a lot. Eight healthy young men were studied during three periods of heat exposure in a Finnish sauna bath: at 80 degrees C dry bulb (80 D) and 100 degrees C dry bulb (100 D) temperatures until subjective discomfort, and in 80 degrees C dry heat, […]

Read the full article →

Leptin, Ghrelin, Obesity and The Sauna

March 30, 2011

In the obese leptin is often found to be higher than normal, while ghrelin is found to be below normal. Leptin and ghrelin both are connected with energy intake (eating) and expenditure, and relevant to appetite in particular. The following study found that sauna use while ghrelin fell in the non-obese, it did not fall […]

Read the full article →